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glycogenic acanthosis
Glycogenic acanthosis is a nodular appearance of the mucosa of the esophagus.〔Ghahremani GG, Rushovich AM. Glycogenic acanthosis of the esophagus: radiographic and pathologic features. ''Gastrointest Radiol.'' 1984;9(2):93-8. PMID 6745598.〕 It is seen incidentally in 3.5% of gastroscopies.〔Vadva MD, Triadafilopoulos G. Glycogenic acanthosis of the esophagus and gastroesophageal reflux. ''J Clin Gastroenterol''. 1993 Jul;17(1):79-83. PMID 8409304〕 It is also a common finding during fluoroscopic studies of the esophagus.
==Clinical features==
On gastroscopy, glycogenic acanthosis is seen as a multitude of small raised plaques of 2 mm to 10 mm in size of the same colour as the esophageal mucosa. Biopsies of the lesions show hypertrophied stratified squamous mucosa with glycogen deposition in the mucosa.〔
Clinically, mild glycogenic acanthosis is a normal finding, and does not progress to esophageal cancer or to stricture.〔Pathology Outlines website: http://pathologyoutlines.com/esophagus.html#glycogenic Accessed 6 January 2009.〕 It was originally thought to be associated with gastroesophageal reflux disease (GERD), but the association is not entirely clear.〔 One report also shows an association with celiac disease, but again, this has not shown been beyond that. Extensive glycogenic acanthosis has been shown to be associated with Cowden's syndrome.〔Kay PS, Soetikno RM, Mindelzun R, Young HS. Diffuse esophageal glycogenic acanthosis: an endoscopic marker of Cowden's disease. Am J Gastroenterol. 1997 Jun;92(6):1038-40 PMID 9177527〕
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